Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Biol. Res. (1) Genet. Mol. Biol. (1) Autor Ajaj,Sana Abdulla (1) Al Tassan,Nada (1) Alanazi,Mohammad (1) Colombo,Jucimara (1) Duarte,Márcia Cristina (1) Khan,Wajahatullah (1) Parine,Narasimha Reddy (1) Pathan,Akbar Ali Khan (1) Rossit,Andréa Regina Baptista (1) Shaik,Jilani P (1) Silva,Ana Elizabete (1) Mais... Palavra-chave Polymorphism (2) XRCC1 (2) XRCC3 (2) DNA Repair genes (1) DNA repair (1) Ethnic variability (1) OGG1 (1) Saudi population (1) XPD (1) Mais... Tipo do documento Info:eu-repo/semantics/other (1) Journal article (1) Ano 2013 (1) 2005 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia Biol. Res. Alanazi,Mohammad; Pathan,Akbar Ali Khan; Ajaj,Sana Abdulla; Khan,Wajahatullah; Shaik,Jilani P; Al Tassan,Nada; Parine,Narasimha Reddy. DNA repair is one of the central defense mechanisms against mutagenic exposures. Inherited SNPs of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. Saudi Arabia harbors enormous genetic and cultural diversity. In the present study we aimed to determine the genotype and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 386 healthy individuals residing in the central region of Saudi Arabia and compare them with HapMap and other populations. The genotype and... Tipo: Journal article Palavras-chave: DNA Repair genes; Polymorphism; Saudi population; XRCC1; XRCC3; OGG1; XPD. Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000200007 Polymorphisms of the DNA repair genes XRCC1 and XRCC3 in a Brazilian population Genet. Mol. Biol. Duarte,Márcia Cristina; Colombo,Jucimara; Rossit,Andréa Regina Baptista; Silva,Ana Elizabete. In several DNA repair genes, polymorphisms may result in reduced repair capacity, which has been implicated as a risk factor for various types of cancer. The frequency of the polymorphic alleles varies among populations, suggesting an ethnic distribution of genotypes. We genotyped 300 healthy Southeastern Brazilian individuals (262 of European ancestry and 38 of African ancestry) for polymorphisms of codons 194 and 399 of the XRCC1 base excision repair pathway gene and of codon 241 of the XRCC3 homologous recombination repair pathway gene. The allele frequencies were 0.07 for the Arg194Trp and 0.33 for the Arg399Gln codons of the XRCC1 gene and 0.35 for the Thr241Met codon of the XRCC3 gene. The genotypic frequencies were within Hardy-Weinberg equilibrium.... Tipo: Info:eu-repo/semantics/other Palavras-chave: DNA repair; XRCC1; XRCC3; Polymorphism; Ethnic variability. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300011 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco